COVID-19 trials: declarations of data sharing intentions at trial registration and at publication

Abstract Background The sharing of individual participant-level data from COVID-19 trials would allow re-use and secondary analysis that can help accelerate the identification of effective treatments.The sharing of trial data is not the norm, but the unprecedented pandemic caused by SARS-CoV-2 may serve as an impetus for greater data sharing.We sought to assess the data sharing intentions of interventional COVID-19 trials as declared in trial registrations and publications.

Methods We searched ClinicalTrials.gov and PubMed for COVID-19 interventional trials.We analyzed responses to ClinicalTrials.

gov fields regarding intent to jeff rosenstock buffalo share individual participant level data and analyzed the data sharing statements in eligible publications.Results Nine hundred twenty-four here trial registrations were analyzed.15.

7% were willing to share, of which 38.6% were willing to share immediately upon publication of results.47.

6% declared they were not willing to share.Twenty-eight publications were analyzed representing 26 unique COVID-19 trials.Only seven publications contained data sharing statements; six indicated a willingness to share data whereas one indicated that data was not available for sharing.

Conclusions At a time of pressing need for researchers to work together to combat a global pandemic, intent to share individual participant-level data from COVID-19 interventional trials is limited.

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